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Even so, it would be preferable to stop concomitant administration of those drugs. 4. Doxycycline: Phenobarbital has actually been proven to shorten the 50 %- life of doxycycline for as long as 2 months after barbiturate therapy is discontinued. This system is probably with the induction of hepatic microsomal enzymes that metabolize the antibiotic.

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As with other sedatives and hypnotics, elderly or debilitated clients may well respond to barbiturates with marked excitement, melancholy, or confusion. The systemic effects of exogenous hydrocortisone and endogenous hydrocortisone (cortisol) may very well be diminished by phenobarbital. Hence, this product need to be administered with warning to c

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